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Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity | Science

January 15, 2026Science

Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and excessive interleukin (IL)–1β production in macrophages ...

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